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Modest-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/nine) induce a lytic type of cell Dying known as pyroptosis in mouse and human monocytes and macrophages1,two. In mouse myeloid cells, Dpp8/9 inhibition activates the inflammasome sensor Nlrp1b, which consequently activates Professional-caspase-one to mediate cell death3, eve